Endocrine Abstracts

Introduction: The SNP rs7578597 (Thr1187Ala) of THADA gene was identified in GWA studies as a novel type 2 diabetes risk locus. Nevertheless, subsequent studies of this SNP effect have been inconclusive. In some studies, rs7578597 has been associated with insulin secretion but no significant correlation with type 2 diabetes has been reported. Product of THADA gene is considered to be involved in apoptosis. Whether rs7578597 affects insulin secretion throught the apoptosis of p...

Introduction: Bariatric surgery has been proved to be the most effective treatment for type 2 diabetes mellitus (T2D). Post-operative improvement in insulin sensitivity seems to be partly independent of weight loss and may be affected by changes in incretin secretion. Previous studies reported that the glucose-dependent insulinotropic polypeptide (GIP)-induced enhancement of fat stores may lead to increased insulin resistance. We determinated the effect of laparoscopic adjusta...

Introduction: Activating point mutations in the RAS genes (H-RAS, K-RAS, N-RAS) are reported in thyroid tumors. The aim of this study was to determine the frequency of RAS mutations in 98 patients with thyroid tumors.Methods: DNA was extracted from 72 fresh frozen thyroid samples and 26 paraffin-embedded formalin-fixed samples. The cohort contained 83 PTCs (56 FVPTCs, 14 mixed follicular-classical types, 11 classical variants and two other rare variants)...